Defiler of Instinct

two generic mana one red mana Creature — Phyrexian KavuPower and toughness4/4

First strike

As an additional cost to cast red permanent spells, you may pay 2 life. Those spells cost one red mana less to cast if you paid life this way. This effect reduces only the amount of red mana you pay.

Whenever you cast a red permanent spell, this creature deals 1 damage to any target.

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Defiler of Instinct rulings

2022-09-09
You may only pay the additional cost once per permanent spell.
2022-09-09
Some players may make the mental shortcut that the Defilers effectively turn one of the colored mana symbols in the spell’s cost into a Phyrexian colored mana symbol. Despite the similarity in function, this ability does not cause the spells to have Phyrexian mana symbols in their costs. Sorry, Rage Extractor!

Defiler of Instinct keyword rules

First strike Rule 702.7

First strike is a static ability that modifies the rules for the combat damage step. (See rule , “Combat Damage Step.”)

If at least one attacking or blocking creature has first strike or double strike (see rule ) as the combat damage step begins, the only creatures that assign combat damage in that step are those with first strike or double strike. After that step, instead of proceeding to the end of combat step, the phase gets a second combat damage step. The only creatures that assign combat damage in that step are the remaining attackers and blockers that had neither first strike nor double strike as the first combat damage step began, as well as the remaining attackers and blockers that currently have double strike. After that step, the phase proceeds to the end of combat step.

Giving first strike to a creature without it after combat damage has already been dealt in the first combat damage step won’t preclude that creature from assigning combat damage in the second combat damage step. Removing first strike from a creature after it has already dealt combat damage in the first combat damage step won’t allow it to also assign combat damage in the second combat damage step (unless the creature has double strike).

Multiple instances of first strike on the same creature are redundant.